Dr. Mikhail Blagosklonny: Working To Cure Cancer And Aging Related Diseases


Posted by omeditors | Posted in Studying Cancer | Posted on 12-01-2017

Oncologist Mikhail Blagosklonny has spent many years of his life studying cancer and aging. A graduate of St. Petersburg’s the First Pavlov State Medical University, he earned both an M.D. in internal medicine as well as a PhD in cardiology and experimental medicine. A well-respected researcher and scientist on Nature.com, Blagosklonny is a professor at New York’s the Roswell Park Cancer Institute where he teaches oncology. Prior to that he was a New York Medical College, Valhalla assistant professor where he taught medicine from 2002 until 2009.

As a researcher Blagosklonny focuses on the mechanisms underlying aging and effective anti-aging drugs as well as cancer and targeted therapies designed to prevent healthy cells from becoming damaged due to cancer treatment. Mikhail Blagosklonny has also come up with a theory that TOR signaling can play a role in working with issues related to aging and cancer. Blagosklonny has proposed using the popular cancer drug rapamycin to aid in extending life for the elderly. In fact he’s among the most passionate advocates of the use of rapamycin in longevity research.

Blagosklonny has published extensively. He’s had more than 270 papers published in peer-reviewed journals. Add his 25,000 citations and it gives him a h-index of 83. Blagosklonny is also editor-in-chief of Oncotarget, Aging and Cell Cycle on tandfonline.com. He’s also Cancer Biology & Therapy’s associate editor as well as a Cell Death & Differentiation editorial board member. Blagosklonny is also known as one of the hyperfunction theory’s major proponents. Hyperfunction theory holds that life is governed by a developmental genetic program and that the aging related diseases are a result of the running on inertia of growth signaling pathways.

According to Blagosklonny aging is not caused by oxidative damage. Instead it’s collateral damage caused by mTOR-driven inflammatory processes like dementia, diabetes, obesity, osteoporosis, hypertension, atherosclerosis and cancer that underlying aging processes. According to the theory people’s lifespan can be lengthened by calming the mTOR pathway as people age. The theory on researchgate.net holds that this can be done using drug compounds like rapamycin or metformin, using dietary protein restrictions, intermittent fasting and regular exercise.

Dr. Blagosklonny is also doing very meaningful work at the Roswell Park Cancer Institute at http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=3740. There he is part of the team working to understand, prevent and find ways to cure cancer. The center was founded in 1898. It is a member of the National Comprehensive Cancer Network and partners with national and international collaborative programs.